Yazar "Yoltaş, Ayşegül" için listeleme
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An alternative approach to wound healing field; New composite films from natural polymers for Mupirocin dermal delivery
Okur, Neslihan Üstündağ; Hökenek, Nesrin; Okur, Mehmet Evren; Ayla, Şule; Yoltaş, Ayşegül; Siafaka, Panoraia I.; Cevher, Erdal (Elsevier, 2019)In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release ... -
Development and characterization of voriconazole loaded in situ gel formulations for ophthalmic application
Üstündağ Okur, Neslihan; Yoltaş, Ayşegül; Yozgatlı, Vildan (Turkish Pharmacists Assoc, 2016)The aim of the this research was to prepare and evaluate the potential use of in situ gel formulations for ocular delivery of voriconazole for the treatment of fungal keratitis. An in situ gelling system was used to increase ... -
Evaluation of burn wound healing activity of novel fusidic acid loaded microemulsion based gel in male Wistar albino rats
Okur, Mehmet Evren; Ayla, Şule; Yozgatlı, Vildan; Aksu, Neşe Buket; Yoltaş, Ayşegül; Orak, Duygu; Sipahi, Hande; Üstündaǧ Okur, Neslihan (Elsevier, 2020)The objective of the present research was to examine the possible usage of microemulsion based gel for fusidic acid (FA) dermal application as burn wound treatment. During the preparation of microemulsion, ethyl oleate as ... -
Evaluation of in situ gel containing pycnogenol for cutaneous wound healing
Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ... -
Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches
Okur, Mehmet Evren; Çiçek Polat, Derya; Özbek, Hanefi; Yılmaz, Sezen; Yoltaş, Ayşegül; Arslan, Rana (Bentham Science Publ Ltd, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers
Üstündağ Okur, Neslihan; Yozgatlı, Vildan; Okur, Mehmet Evren; Yoltaş, Ayşegül; Siafaka, Panoraia, I. (Elsevier Science Bv, 2019)The aim of this research was to evaluate the potential use of in situ gel formulations for voriconazole ocular delivery as fungal keratitis treatment. The in situ gelling system was applied to increase residence time and ... -
New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
Arpa, Muhammet Davut; Yoltaş, Ayşegül; Onay Tarlan, Ecehan; Şahin Şenyüz, Cemre; Sipahi, Hande; Aydın, Ahmet; Üstündağ Okur, Neslihan (Taylor and Francis Ltd., 2020)The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
Üstündağ Okur, Neslihan; Filippousi, Maria; Okur, Mehmet Evren; Ayla, Şule; Çağlar, Emre Şefik; Yoltaş, Ayşegül; Siafaka, Panoraia I (Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits
Okur, Mehmet Evren; Ayla, Şule; Polat, Derya Çiçek; Günal, Mehmet Yalçın; Yoltaş, Ayşegül; Biçeroğlu, Özge (Wiley, 2018)ObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, ... -
Preparation and evaluation of QbD based fusidic acid loaded in situ gel formulations for burn wound treatment
Aksu, Neşe Buket; Yozgatlı, Vildan; Okur, Mehmet Evren; Ayla, Şule; Yoltaş, Ayşegül; Üstündağ Okur, Neslihan (Elsevier, 2019)The purpose of this research was to prepare and evaluate the potential use of in situ gel formulations for dermal delivery of fusidic acid for burn wound treatment. Temperature sensitive in situ gels were successfully ... -
Promising nanogels loaded with usnic acid for oral ulcer treatment: Development, characterization, and in vivo evaluation in rabbits
Coşkunmeriç, Nesrin; Üstündağ Okur, Neslihan; Okur, Mehmet Evren; Ayla, Şule; Yoltaş, Ayşegül; Karavana, Sinem Yaprak (Taylor and Francis Ltd., 2021)This study aimed to present an effective formulation targeting oral ulcers that will remain in the application site for a longer period, reducing the frequency of administration. As a candidate formulation, usnic acid (UA) ... -
Wound healing effects of methanol extract of Laurocerasus officinalis roem
Ayla, Şule; Okur, Mehmet Evren; Günal, Mehmet Yalçın; Özdemir, Ekrem Musa; Çiçek Polat, Derya; Yoltaş, Ayşegül; Biçeroğlu, Özge; Karahüseyinoğlu, Serçin (Taylor & Francis Ltd, 2019)Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using ...